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Moreover, in another study, L-theanine effectively regulated the secretion of cytokines such as IFN-γ, IL-2, IL-4, IL-10, IL-12, and TNF-α except for IL-6 by activating the mRNA and protein expression of Ras-related protein Rap-1A (Rap1A), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and farnesyl diphosphate synthase (FDPs) in the mevalonate synthesis pathway of rat splenic lymphocytes (93)